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Our deepest condolences goes out to the Biden family as they deal with the loss of their son, husband and brother. Beau suffered from brain cancer and died at the age of 46.

See the official statement from the Biden family and the White House:

It is with broken hearts that Hallie,Hunter, Ashley, Jill and I announce the passing of our husband, brother and son, Beau, after he battled brain cancer with the same integrity, courage and strength he demonstrated every day of his life,” Biden said in his statement.

“The entire Biden family is saddened beyond words. We know that Beau’s spirit will live on in all of us—especially through his brave wife, Hallie, and two remarkable children, Natalie and Hunter,” he continued.

Read the rest of the family’s official statement below:

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R.I.P